hhv-6 dna and antibody detection in plasma and pbmc of multiple sclerosis patients and healthy control in north of iran
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abstract
multiple sclerosis (ms) is defined by the presence of inflammatory demyelinating plaques in the central nervous system (cns). it has been indicated that human herpes virus 6 (hhv-6) may play role in pathogenesis of ms. background: the aim of this study was to determine the presence of hhv-6 dna and anti hhv-6 igg in ms patients and controls. methods: blood samples from 59 patients with ms and 59 healthy controls were collected. dna extraction and real-time pcr based on (syber green) were done in the peripheral blood mononuclear cells (pbmcs) and plasma specimens. anti-hhv-6 igg was measured by elisa technique. demographic and clinical data were collected and entered in spss 16 and analyzed. results: hhv-6 dna was found in the plasma sample of 1 (1.7%) of 59 ms patients. there was no hhv-6 dna in pbmcs of the ms patients and controls and plasma of control group. anti- hhv-6 igg antibody was seen in 84.7 % of ms patients and 82.1% of control group. conclusion: there was no significant relation based on presence of hhv-6 dna and antibody between ms patients and controls in north of iran.
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HHV-6 DNA and Antibody Detection in Plasma and PBMC of Multiple Sclerosis Patients in North of Iran
Abstract Background and Aims: Multiple sclerosis (MS) is defined by the presence of inflammatory demyelinating plaques in the central nervous system (CNS). It has been indicated that human herpes virus 6 (HHV-6) may play role in pathogenesis of MS. The aim of this study was to determine the presence of HHV-6 DNA and anti HHV-6 IgG in MS patients and controls. Materials and Methods: Bloo...
full texthhv-6 dna and antibody detection in plasma and pbmc of multiple sclerosis patients in north of iran
abstract background and aims: multiple sclerosis (ms) is defined by the presence of inflammatory demyelinating plaques in the central nervous system (cns). it has been indicated that human herpes virus 6 (hhv-6) may play role in pathogenesis of ms. the aim of this study was to determine the presence of hhv-6 dna and anti hhv-6 igg in ms patients and controls. materials and methods: blood sample...
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Journal title:
iranian journal of virologyجلد ۹، شماره ۲، صفحات ۱۶-۲۱
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